Download Advances in Clinical Chemistry, Vol. 23 by A.L & Schwartz, Morton Latner PDF

Download Advances in Clinical Chemistry, Vol. 23 by A.L & Schwartz, Morton Latner PDF

By A.L & Schwartz, Morton Latner

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The increased basal enzyme activity [on a dose 10 times that recommended by Luhby (L12)] was explained by induction of the red cell enzyme, indicating yet another factor which needs careful attention if vitamin status is to be adequately assessed. Wien (W11) studied the vitamin B, status of 238 Nigerian women by measuring the erythrocyte alanine aminotransferase activity, both with and without in vitro stimulation by pyridoxal 5'-phosphate. Forty-nine women used an intrauterine contraceptive device, 47 used injectable progestogen, and 48 used oral contraceptives; 94 new patients had not used any contraceptive during the preceding 6 months.

Other effects noted in the offspring of rats made vitamin B, deficient during pregnancy or lactation include delay in onset of reflexes and advanced neuromotor coordination (A18), major malformations such as omphalocele, exencephaly, cleft palate, micrognathia, splenic hypoplasia (DIO), alterations in DNA content of the fetal brain (D11, D12), and impaired elongation of fatty acids in brain, leading to impaired myelination (C16). Desaturation of linoleic acid (TS), reduced 2’,3’-cyclic nucleotide 3’-phosphohydrolase activity (M21), and reduced phosphoserine aminotransferase (B3) are other causes of demyelination brought about by restricting vitamin B, in the neonatal period of rat development.

Previously, Morales and Lincoln (M17) had reported that 20 children on isonicotinic acid hydrazide showed no signs of deficiency when the dose was less than 10 mg/kg body weight daily. L-Penicillamine (a-amino-p-thioisovaleric acid) was shown to cause vitamin B, depletion in rats by Kuchinskas and his team in 1957 (K13) and Ueda et al. (Ul),and it was found that both the D and L isomers can form thiazolidine derivatives with pyridoxal phosphate by nonenzymic reaction. D-Penicillamine is used in the long-term treatment of Wilson’s disease and in the management of heavy metal poisoning, as well as in the treatment of some patients with cystinuria; hence, it is important to monitor the vitamin B, status of these patients regularly or to ensure that more than an adequate concentration of the vitamin is present in the diet (El).

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