Download Allogeneic Stem Cell Transplantation: Clinical Research and by Frederick R. Appelbaum MD (auth.), Mary J. Laughlin MD, PDF

Download Allogeneic Stem Cell Transplantation: Clinical Research and by Frederick R. Appelbaum MD (auth.), Mary J. Laughlin MD, PDF

By Frederick R. Appelbaum MD (auth.), Mary J. Laughlin MD, Hillard M. Lazarus MD (eds.)

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Extra info for Allogeneic Stem Cell Transplantation: Clinical Research and Practice

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Between March 1996 and July 1999, 172 patients, including 22 with ALL with a median age of 42 yr, were randomly assigned to receive bone marrow or filgrastim-mobilized PBSC from HLA-identical relatives for hematopoietic rescue after dose-intensive chemotherapy. After randomization, patients were stratified according to age (<30 or >30 yr), and stage of cancer (for ALL, CR1 was defined as less advanced; for all others, it was defined as advanced), with roughly equal numbers in the two groups. It was concluded from this study that allogeneic peripheral blood cells used for hematopoietic rescue restore blood counts faster than bone marrow without increasing the risk of GVHD.

Fefer A, Sullivan K, Weiden P, et al. Graft versus leukemia effect in man: the relapse rate of acute leukemia is lower after allogeneic than after syngeneic marrow transplantation. In: Truitt R, Gale RP, Bortin MM, eds. Cellular Immunotherapy of Cancer. Alan R Liss, New York, 1987, pp. 401–408. 62. Leith CP, Kopecky KJ, Godwin JE, et al. Acute myeloid leukemia in the elderly: assessment of multidrug resistance (MDRI) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy.

Alan R Liss, New York, 1987, pp. 401–408. 62. Leith CP, Kopecky KJ, Godwin JE, et al. Acute myeloid leukemia in the elderly: assessment of multidrug resistance (MDRI) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. A Southwest Oncology Group study. Blood 1997;89:3323–3329. 63. Storb R, Yu C, McSweeney P. Mixed chimerism after transplantation of allogeneic hematopoietic cells. In: Thomas ED, Blume KG, Forman SJ, eds. Hematopoietic Cell Transplantation, 2nd ed.

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